Manager’s internal PDF generator does not currently support a lot of font attributes. In order to handle the many demands that come with 80+ languages and their various alphabets/ideographs/etc., it uses Google’s Noto font, no matter what you might have used. Likewise, there are some about constraints that may not be necessary for the way you have configured Manager, but are needed for other potential configurations. As a result, it can be problematic getting too wild with document design. Remember, this is an accounting program. And accounting is supposed to be boring.
As for your currency/number format issues, I would try changing your settings then changing back. Perhaps something got mixed up in your update. I just changed a business to CAD and your number format, and this is what it produces:
If the problem persists, post a screen shot or two illustrating the issue.